Atypical parapharyngeal branchial cyst – case report

Authors

  • Sandra Sousa Hospital CUF Descobertas, Lisboa, Portugal https://orcid.org/0000-0002-1322-8966
  • Pedro Sousa Hospital CUF Descobertas, Lisboa, Portugal
  • Pedro Montalvão Hospital CUF Descobertas, Lisboa, Portugal
  • Alberto Santos Hospital CUF Descobertas, Lisboa, Portugal

DOI:

https://doi.org/10.34631/sporl.3147

Keywords:

Branchial cyst, parapharyngeal space, surgical excision, transcervical approach

Abstract

Parapharyngeal branchial cysts are a rare entity, with approximately 40 cases reported in the literature, and surgical excision is the treatment of choice. We present a case of a 34-year-old man, with no relevant medical history, evaluated due to snoring and obstructive sleep apnea. Clinical examination revealed a submucosal swelling of the right lateral oropharyngeal wall, extending to the hypopharynx. MRI identified a cystic lesion in the parapharyngeal space, suggesting a second branchial cleft cyst. The patient underwent surgical excision via a transcervical approach, and histological analysis confirmed the diagnosis. Postoperatively, right vocal cord paralysis was identified, with satisfactory functional recovery after rehabilitation. At 12-month follow-up, no recurrence was observed on MRI. This case highlights the rarity of branchial cleft cysts in parapharyngeal space, the major role of MRI in diagnosis and surgical planning, and the need for awareness of potential complications associated with the treatment of lesions in anatomically complex regions.

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References

Adams A, Mankad K, Offiah C, Childs L. Branchial cleft anomalies: a pictorial review of embryological development and spectrum of imaging findings. Insights Imaging. 2016 Feb;7(1):69-76. doi: 10.1007/s13244-015-0454-5.

Hamadi I, Lutfi L, Mohammed A, Alkhadem, Z. Branchial cyst in the parapharyngeal space: a case report. Dubai Med J. 2021;4:171–174. doi:10.1159/000514893.

Magdy EA, Fadali GA, Seif-Elnasr M, Fathalla MF. Unusual isolated parapharyngeal second branchial cleft cyst: a case report and literature review. Case Rep Otolaryngol. 2020 Dec 8:2020:8814071. doi: 10.1155/2020/8814071.

Gao S, Xu Q, Yi Q. Endoscopically assisted transoral resection of a Bailey type IV second branchial cleft cyst: a case report. Medicine (Baltimore). 2021 Jan 22;100(3):e24375. doi: 10.1097/MD.0000000000024375.

Piccin O, Cavicchi O, Caliceti U. Branchial cyst of the parapharyngeal space: report of a case and surgical approach considerations. Oral Maxillofac Surg. 2008 Dec;12(4):215-7. doi: 10.1007/s10006-008-0132-6.

Deka A, Das S, Sarma N, Bhatia A, Chakraborty S. Unusual branchial cleft cyst at parapharyngeal space: case report and a review of literature. Indian J Otolaryngol Head Neck Surg. 2023 Dec;75(4):4047-4049. doi: 10.1007/s12070-023-04027-2.

Akaash H, Shahid F, Khan MS. An unusual presentation of type-IV second branchial cyst: a case report. Indian J Otolaryngol Head Neck Surg. 2022 Dec;74(Suppl 3):6292-6295. doi: 10.1007/s12070-021-03034-5.

Yang YN, Hong YT. Intraoral Approach for parapharyngeal branchial cleft cysts. Ear Nose Throat J. 2024 Sep;103(9):NP541-NP544. doi: 10.1177/01455613211067846.

Gupta M, Gupta M. A rare parapharyngeal space branchial cleft cyst. BMJ Case Rep. 2013 Apr 29:2013:bcr2013008952. doi: 10.1136/bcr-2013-008952.

Kadowaki Y, Hirano T, Umemoto S, Fujinaga M, Suzuki M. Combined transoral and endoscopic marsupialization for a parapharyngeal space cyst. Otolaryngol Case Rep. 2021 Sep; 20: 100324, ISSN 2468-5488. doi: 10.1016/j.xocr.2021.100324

Saussez S, De Maesschalk T, Mahillon V, Filleul O, Louryan S. Second branchial cyst in the parapharyngealspace: a case report. Auris Nasus Larynx. 2009 Jun;36(3):376-9. doi: 10.1016/j.anl.2008.06.005

Howlett J, Horwich P, Bullock MJ, Taylor SM, Hart R, Trites J. et al. An unusual presentation of a branchial cleft cyst in a 70-year-old. Otolaryngol Case Rep. 2018 Mar; 6:16-18. doi:10.1016/j.xocr.2017.11.005.

Dallan I, Seccia V, Bruschini L, Ciancia E, Franceschini SS. Parapharyngeal cyst: considerations on embryology, clinical evaluation, and surgical management. J Craniofac Surg. 2008 Nov;19(6):1487-90. doi: 10.1097/SCS.0b013e318189724d.

López F, Suárez C, Vander Poorten V, Mäkitie A, Nixon IJ, Strojan P. et al. Contemporary management of primary parapharyngeal space tumors. Head Neck. 2019 Feb;41(2):522-535. doi: 10.1002/hed.25439.

Jung SC, Oh HJ, Do NY, Park JH. Unusual presentation of second branchial cleft cyst: case reports and literature review. Korean J Otorhinolaryngol-Head Neck Surg 2016;59(2):140-4. doi:10.3342/kjorl-hns.2016.59.2.140.

Xu V, Gill KS, Goldfarb J, Bovenzi C, Moayer R, Krein H. et al. First bite syndrome after parotidectomy: a case series and review of literature. Ear Nose Throat J. 2022 Dec;101(10):663-667. doi: 10.1177/0145561320980179.

Published

2026-06-10

How to Cite

Sousa, S., Sousa, P., Montalvão, P., & Santos, A. (2026). Atypical parapharyngeal branchial cyst – case report. Portuguese Journal of Otorhinolaryngology and Head and Neck Surgery, 64(2), 223–227. https://doi.org/10.34631/sporl.3147

Issue

Section

Case Report