Predictive Factors of Progression to Carcinoma in Vocal Fold Leucoplakia

Authors

  • João Viana Pinto Serviço de Otorrinolaringologia, CHUSJ, Porto; Unidade de Otorrinolaringologia, Departamento de Cirurgia e Fisiologia, Faculdade de Medicina da Universidade do Porto; Centro de Investigação em Tecnologias e Serviços de Saúde (CINTESIS), Porto https://orcid.org/0000-0002-6485-6786
  • José João Ruas Serviço de Otorrinolaringologia, CHUSJ, Porto; Unidade de Otorrinolaringologia, Departamento de Cirurgia e Fisiologia, Faculdade de Medicina da Universidade do Porto https://orcid.org/0000-0003-3397-3530
  • António Andrade Serviço de Otorrinolaringologia, CHUSJ, Porto; Unidade de Otorrinolaringologia, Departamento de Cirurgia e Fisiologia, Faculdade de Medicina da Universidade do Porto https://orcid.org/0000-0002-5192-7901
  • João Aragão Rodrigues Serviço de Anatomia Patológica, Centro Hospitalar Universitário de São João, EPE, Porto https://orcid.org/0000-0002-5807-4622
  • Isabel Pinto Serviço de Otorrinolaringologia, CHUSJ, Porto; Unidade de Otorrinolaringologia, Departamento de Cirurgia e Fisiologia, Faculdade de Medicina da Universidade do Porto https://orcid.org/0000-0002-2093-9109
  • Manuel Mendes Leal Serviço de Otorrinolaringologia, CHUSJ, Porto; Unidade de Otorrinolaringologia, Departamento de Cirurgia e Fisiologia, Faculdade de Medicina da Universidade do Porto https://orcid.org/0000-0002-0456-9777
  • Fernando Vales Serviço de Otorrinolaringologia, CHUSJ, Porto; Unidade de Otorrinolaringologia, Departamento de Cirurgia e Fisiologia, Faculdade de Medicina da Universidade do Porto https://orcid.org/0000-0002-5545-2720
  • Carla Pinto Moura Serviço de Otorrinolaringologia, CHUSJ, Porto; Serviço de Genética Médica, Centro Hospitalar Universitário S. João/Faculdade Medicina da Universidade do Porto; I3S, Instituto de Investigação e Inovação em Saúde, Universidade do Porto https://orcid.org/0000-0001-7291-6163

DOI:

https://doi.org/10.34631/sporl.1057

Keywords:

Leucoplakia, laryngeal cancer, vocal fold premalignant lesion

Abstract

Objectives: To assess possible risk factors for progression in vocal fold leucoplakia.

Study Design: Observational retrospective study.

Material and Methods: Clinical data analysis of every patient submitted to microlaryngoscopy (MLS) with biopsy, excisional whenever possible, of vocal fold leucoplakia from January 2010 to December 2020 in the Otorhinolaryngology department of a tertiary hospital centre.

Results: One or more MLS were performed on 163 patients. Histological results were squamous cell carcinoma in 50 (30,7%), pre-malignant lesion in 68 (41,7%) and benign lesion in 45 (27,6%). Patients with a more severe dysplasia grade on the first biopsy had higher rates of malignant transformation (p=0,017). On the other hand, age, gender, tobacco or alcohol consumption, smoking cessation or the presence of gastroesophageal reflux disease weren’t associated with the progression to carcinoma.

Conclusion: The main risk factor for progression to carcinoma is the histological grade on the first biopsy.

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Published

2022-09-25

How to Cite

Viana Pinto, J., Ruas, J. J., Andrade, A., Aragão Rodrigues, J., Pinto, I., Mendes Leal, M., Vales, F., & Pinto Moura, C. (2022). Predictive Factors of Progression to Carcinoma in Vocal Fold Leucoplakia. Portuguese Journal of Otorhinolaryngology and Head and Neck Surgery, 60(3), 237–242. https://doi.org/10.34631/sporl.1057

Issue

Vol. 60 No. 3 (2022): September

Section

Original Article

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